Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer

Functional genomics pipeline identifies CRL4 inhibition for the treatment of ovarian cancer

Abstract Background The goal of precision oncology is to find effective therapeutics for every patient. Through the inclusion of emerging therapeutics in a high‐throughput drug screening platform, our functional genomics pipeline inverts the common paradigm to identify patient populations that are l...

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Main Authors: Sally E. Claridge, Shalini Nath, Anneliese Baum, Richard Farias, Julie‐Ann Cavallo, Nile M. Rizvi, Lamberto De Boni, Eric Park, Genesis Lara Granados, Matthew Hauesgen, Ruben Fernandez‐Rodriguez, Eda Nur Kozan, Evgeny Kanshin, Khoi Q. Huynh, Peng‐Jen Chen, Kenneth Wu, Beatrix Ueberheide, Juan Miguel Mosquera, Fred R. Hirsch, Robert J. DeVita, Olivier Elemento, Chantal Pauli, Zhen‐Qiang Pan, Benjamin D. Hopkins
Format: Article
Language:English
Published: Wiley 2025-02-01
Series:Clinical and Translational Medicine
Subjects:
CRL4
functional genomics
ovarian cancer
precision oncology
Online Access:https://doi.org/10.1002/ctm2.70078
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https://doi.org/10.1002/ctm2.70078

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