Programmed death-1 inhibition increases vaccine-induced T-cell infiltration in patients with prostate cancer

Programmed death-1 inhibition increases vaccine-induced T-cell infiltration in patients with prostate cancer

Background Prostate cancer (PC) is the most frequently diagnosed cancer in men worldwide, making up 21% of all cancer cases. Although generally slow-growing, 370,000 men die from PC yearly. Immune checkpoint inhibitors (ICIs) are currently only indicated for the rare cases of microsatellite instabil...

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Main Authors: Colin Pritchard, Renee N Donahue, Jeffrey Schlom, James L Gulley, Ravi A Madan, Fatima Karzai, Amy Hankin, Jennifer L Marté, Ismail Baris Turkbey, Yo-Ting Tsai, Manuk Manukyan, Moniquea Williams, William Dahut, Shania Bailey, Wiem Lassoued, Michell Manu, Peter Pinto, Daniel Burnett, Elisabetta Xue, Kenneth D Canubas, Antonios Papanicolau-Sengo, Zhigang Kang, Sam Sater
Format: Article
Language:English
Published: BMJ Publishing Group 2025-06-01
Series:Journal for ImmunoTherapy of Cancer
Online Access:https://jitc.bmj.com/content/13/6/e010851.full
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https://jitc.bmj.com/content/13/6/e010851.full

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