Identification of nuclear valosin-containing-protein-like as a target of anti-nuclear autoantibodies in systemic sclerosis

Identification of nuclear valosin-containing-protein-like as a target of anti-nuclear autoantibodies in systemic sclerosis

ObjectiveTo identify the target antigen of an anti-nuclear autoantibody (ANA) from a patient with a suspected systemic autoimmune disease and to study the autoantibody’s clinical association.MethodsThe index patient serum was screened for autoantibodies using indirect immunofluorescence assay (IFA)...

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Main Authors: Zitao Zeng, Ramona Miske, Madeleine Scharf, Yvonne Denno, Anthonina Ott, Stefanie Brakopp, Bianca Teegen, Winfried Stöcker, Elise Siegert, Sandra Saschenbrecker, Christian Probst, Lars Komorowski
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-01-01
Series:Frontiers in Medicine
Subjects:
ANA
anti-nuclear autoantibodies
autoimmune disease
biomarker
diagnosis
nuclear valosin-containing-protein-like
Online Access:https://www.frontiersin.org/articles/10.3389/fmed.2024.1477365/full
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https://www.frontiersin.org/articles/10.3389/fmed.2024.1477365/full

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