Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones?

Does Ortho-Substitution Enhance Cytotoxic Potencies in a Series of 3,5-Bis(benzylidene)-4-piperidones?

<b>Background:</b> A series of 3,5-benzylidene-4-piperidones, <b>1a</b>–<b>n</b>, were prepared to evaluate the hypothesis that the placement of different groups in the ortho-location of the aryl rings led to compounds with greater cytotoxic potencies than structu...

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Bibliographic Details
Main Authors: Subhas S. Karki, Umashankar Das, Jan Balzarini, Erik De Clercq, Hiroshi Sakagami, Yoshihiro Uesawa, Praveen K. Roayapalley, Jonathan R. Dimmock
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Medicines
Subjects:
4-piperidones
conjugated unsaturated ketones
ortho-effect
cytotoxicity
tumor-selective toxicity
QSAR
Online Access:https://www.mdpi.com/2305-6320/11/8/19
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