Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS.

Structural definition of hSP-D recognition of Salmonella enterica LPS inner core oligosaccharides reveals alternative binding modes for the same LPS.

The crystal structures of a biologically and therapeutically active recombinant homotrimeric fragment of native human SP-D (hSP-D) complexed with the inner core oligosaccharide of the Salmonella enterica sv Minnesota rough strains R5 and R7 (rough mutant chemotypes Rc and Rd1) have been determined....

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Main Authors: Jamie R Littlejohn, Ruben F da Silva, William A Neale, Carrie C Smallcombe, Howard W Clark, Rose-Marie A Mackay, Alastair S Watson, Jens Madsen, Derek W Hood, Ian Burns, Trevor J Greenhough, Annette K Shrive
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2018-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199175&type=printable
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https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0199175&type=printable

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