Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients

Detection of diagnostic somatic copy number alterations from cerebrospinal fluid cell-free DNA in brain tumor patients

Abstract The gold standard for precise diagnostic classification of brain tumors requires tissue sampling, which carries relevant procedural risks. Brain biopsies often have limited sensitivity and fail to address tumor heterogeneity, because small tissue parts are being examined. This study aims to...

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Main Authors: Svenja Klinsing, Julia Beck, Katharina J. Weber, Kirsten Bornemann-Kolatzki, Mareike Dettki, Hans Urban, Bastian Roller, Kai U. Chow, Henning Reis, Peter J. Wild, Ekkehard Schuetz, Philipp Euskirchen, Joachim P. Steinbach, Michael W. Ronellenfitsch, Patrick N. Harter, Pia S. Zeiner
Format: Article
Language:English
Published: BMC 2024-11-01
Series:Acta Neuropathologica Communications
Subjects:
Cell-free DNA
Cerebrospinal fluid
Liquid biopsy
Next-generation sequencing
Brain tumor
Online Access:https://doi.org/10.1186/s40478-024-01887-9
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https://doi.org/10.1186/s40478-024-01887-9

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