7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis

7-hydroxycoumarin ameliorates ulcerative colitis in mice by inhibiting the MAPK pathway and alleviating gut microbiota dysbiosis

Abstract Objective This research aimed to delineate the pharmacological mechanisms of 7-Hydroxycoumarin (7-HC) on ulcerative colitis (UC) employing network pharmacology and experimental validation. Methods To investigate the therapeutic effects of 7-HC on UC, a UC mouse model was established through...

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Bibliographic Details
Main Authors: Mengqi Liu, Huayi Sun, Hao Fu, Lingping Fu, Xiao Zheng, Yu Chen
Format: Article
Language:English
Published: BMC 2024-11-01
Series:BMC Gastroenterology
Subjects:
7-hydroxycoumarin
Ulcerative colitis
Network pharmacology
MAPK signaling pathway
Gut microbiome
Online Access:https://doi.org/10.1186/s12876-024-03499-y
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https://doi.org/10.1186/s12876-024-03499-y

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