C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

C. elegans SIRT6/7 homolog SIR-2.4 promotes DAF-16 relocalization and function during stress.

FoxO transcription factors and sirtuin family deacetylases regulate diverse biological processes, including stress responses and longevity. Here we show that the Caenorhabditis elegans sirtuin SIR-2.4--homolog of mammalian SIRT6 and SIRT7 proteins--promotes DAF-16-dependent transcription and stress-...

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Bibliographic Details
Main Authors: Wei-Chung Chiang, Daniel X Tishkoff, Bo Yang, Joshua Wilson-Grady, Xiaokun Yu, Travis Mazer, Mark Eckersdorff, Steven P Gygi, David B Lombard, Ao-Lin Hsu
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2012-09-01
Series:PLoS Genetics
Online Access:https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002948&type=printable
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https://journals.plos.org/plosgenetics/article/file?id=10.1371/journal.pgen.1002948&type=printable

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