Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp: A repeatability study in people with T2DM and overweight/obesity

Tissue-specific and whole-body insulin sensitivity by integrated imaging and hyperinsulinemic euglycemic clamp: A repeatability study in people with T2DM and overweight/obesity

Abstract Background Assessment of glucose uptake by PET imaging under hyperinsulinemic euglycemic clamp (HEC) is an insightful tool for quantification of insulin resistance, a hallmark of diabetes and an area of interest in drug development. To enable the use of the method in metabolic trials, the r...

Full description

Saved in:
Bibliographic Details
Main Authors: Iina Laitinen, Helena Litorp, Folke Sjöberg, Simon Ekström, Henrik Haraldsson, Stefan Pierrou, Alexander Korenyushkin, Joel Kullberg, Sudeepti Southekal, Ming Lu, Tamer Coskun, Zvonko Milicevic, Lars Johansson
Format: Article
Language:English
Published: SpringerOpen 2025-08-01
Series:EJNMMI Research
Subjects:
T2DM
Insulin resistance
FDG
PET/MRI
Repeatability
Online Access:https://doi.org/10.1186/s13550-025-01298-4
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1186/s13550-025-01298-4

Similar Items