Interferons and Toxoplasma gondii shape PD-L1 regulation in retinal barrier cells: the critical role of proteases

Interferons and Toxoplasma gondii shape PD-L1 regulation in retinal barrier cells: the critical role of proteases

IntroductionThe apicomplexan parasite Toxoplasma gondii establishes chronic infection in the central nervous system, including the retina, causing ocular toxoplasmosis (OT). This persistence relies on a fine balance between inflammatory and immunomodulatory mechanisms, especially in the immune-privi...

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Bibliographic Details
Main Authors: Benjamin Geiller, Camila Cevallos, Iuliia Tsybenko, Lydia Arnoux, Marie-Paule Felder-Schmittbuhl, Alexander W. Pfaff
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Immunology
Subjects:
Toxoplasma gondii
ocular toxoplasmosis
interferons
PD-L1
retina
immune privilege
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607247/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1607247/full

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