A humanized anti-Toll like receptor 4 antibody Fab fragment inhibits pro-inflammatory responses induced by lipopolysaccharide through TLR4 in vitro and in vivo

A humanized anti-Toll like receptor 4 antibody Fab fragment inhibits pro-inflammatory responses induced by lipopolysaccharide through TLR4 in vitro and in vivo

Introduction: Toll like receptor 4 (TLR4) and its co-receptor MD-2 recognize bacterial lipopolysaccharide (LPS), initiating responses to infections caused by Gram-negative bacteria. TLR4 also plays a role in various pathological processes, including viral infections and sterile inflammation. Howeve...

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Bibliographic Details
Main Authors: Wenkai Zheng, Fang Xie, Shuping Si, Xi Xiong, Jing Xu, Chuanxia Yao, Cong Li, Jin Zhu, Ping Li, Binggang Cai, Maorong Wang
Format: Article
Language:English
Published: The Journal of Infection in Developing Countries 2025-06-01
Series:Journal of Infection in Developing Countries
Subjects:
TLR4 signaling
sepsis
anti-inflammatory therapy lipopolysaccharide
toll like receptor 4 signaling
inflammation
Online Access:https://www.jidc.org/index.php/journal/article/view/20194
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https://www.jidc.org/index.php/journal/article/view/20194

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