In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol

In vitro and in silico neuroprotective evaluation of new biotransformation metabolites of (-)-α-bisabolol

Abstract Biotransformation of (-)-α-bisabolol (1) was investigated by screening twenty-two fungal strains in an effort to produce new more polar and potentially bioactive metabolites. Three fungi were selected for scale-up biotransformation: Cordyceps sinensis, Alternaria alternata and Aspergillus f...

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Bibliographic Details
Main Authors: Reham Mansour, Ramadan A. Eldomany, Amira Mira, Mohamed A. Sabry, Saleh H. El-sharkawy, Amal F. Soliman
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Bisabolol
Biotransformation
Hamanasic acid A
COX inhibitors
Cholinesterase inhibitors
Neuroprotective
Online Access:https://doi.org/10.1038/s41598-025-11694-4
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https://doi.org/10.1038/s41598-025-11694-4

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