Differential pre-mRNA splicing regulates Nnat isoforms in the hypothalamus after gastric bypass surgery in mice.

<h4>Background</h4>Neuronatin (NNAT) is an endoplasmic reticulum proteolipid implicated in intracellular signalling. Nnat is highly-expressed in the hypothalamus, where it is acutely regulated by nutrients and leptin. Nnat pre-mRNA is differentially spliced to create Nnat-α and -β isofor...

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Main Authors: William R Scott, Cigdem Gelegen, Keval Chandarana, Efthimia Karra, Ahmed Yousseif, Chloé Amouyal, Agharul I Choudhury, Fabrizio Andreelli, Dominic J Withers, Rachel L Batterham
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2013-01-01
Series:PLoS ONE
Online Access:https://journals.plos.org/plosone/article/file?id=10.1371/journal.pone.0059407&type=printable
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