Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress

Supplementing sialic acid analogs overcomes radiotherapy resistance in triple-negative breast cancer by exacerbating ER stress

Radiotherapy is a cornerstone treatment for triple-negative breast cancer (TNBC), and its incorporation has significantly delayed tumor recurrence. However, the emergence of radiotherapy resistance remains a major clinical challenge, substantially compromising treatment efficacy. Sialylation play a...

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Bibliographic Details
Main Authors: Muwen Yang, Dongni Shi, Jianbo Lyu, Yibing Pan, Yiyang Lyv, Xiangfu Chen, Ying Ouyang, Yajie Liu, Yue Li, Libing Song
Format: Article
Language:English
Published: Elsevier 2025-09-01
Series:Redox Biology
Subjects:
ST3GAL4
Sialylation
HSP90B1
Oxidative stress
Radiosensitization
Online Access:http://www.sciencedirect.com/science/article/pii/S2213231725002253
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