Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume‐loading

Dual inhibition of TGFβ and PDGF improves RV remodeling and function in response to RV pressure or volume‐loading

Abstract Right ventricular (RV) pressure and volume loading induce RV fibrosis in association with RV dysfunction, morbidity, and mortality in repaired tetralogy of Fallot. Transforming‐growth factor‐β1 (TGFβ1) and platelet‐derived growth factor (PDGF) activate common downstream signaling pathways v...

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Main Authors: John D. Dauz, Kana Yazaki, Yohei Akazawa, Theo A. Meister, Golam Kabir, Sachiko Kadowaki, Osami Honjo, Scott P. Heximer, Rachel M. Wald, Kim A. Connelly, Mark K. Friedberg
Format: Article
Language:English
Published: Wiley 2025-05-01
Series:Physiological Reports
Subjects:
congenital heart disease
fibrosis
hypertrophy
PDGF
pressure‐loading
right ventricle
Online Access:https://doi.org/10.14814/phy2.70339
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https://doi.org/10.14814/phy2.70339

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