Epitope mapping of SARS-CoV-2 Spike protein using naturally-acquired immune responses to develop monoclonal antibodies

Epitope mapping of SARS-CoV-2 Spike protein using naturally-acquired immune responses to develop monoclonal antibodies

Abstract COVID-19 vaccination strategies are already available almost worldwide. However, it is also crucial to develop new therapeutic approaches, especially for vulnerable populations that may not fully respond to vaccination, such as the immunocompromised. In this project, we predicted 25 B-cell...

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Main Authors: Rubén López-Aladid, Leticia Bueno-Freire, Roc Farriol-Duran, Eduard Porta-Pardo, Ruth Aguilar, Marta Vidal, Alfons Jiménez, Roberto Cabrera, Nil Vázquez, Alexandre López-Gavín, Gemma Moncunill, Montserrat Carrascal, Teresa García, Miquel Lozano, Alberto L. García-Basteiro, Carlota Dobaño, Martalu D. Pazos, M.-Carmen Estevez, Laura M. Lechuga, Antoni Torres, Laia Fernández-Barat
Format: Article
Language:English
Published: Nature Portfolio 2025-05-01
Series:Scientific Reports
Subjects:
Antibody
Immunoassay
Serology
SARS-CoV-2
Recovered patients of COVID-19
IgG
Online Access:https://doi.org/10.1038/s41598-025-00555-9
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https://doi.org/10.1038/s41598-025-00555-9

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