Engineered ipilimumab variants that bind human and mouse CTLA-4

Engineered ipilimumab variants that bind human and mouse CTLA-4

Testing of candidate monoclonal antibody therapeutics in preclinical models is an essential step in drug development. Identification of antibody therapeutic candidates that bind their human targets and cross-react to mouse orthologs is often challenging, especially for targets with low sequence homo...

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Bibliographic Details
Main Authors: Brett Robison, SJ Diong, Anusha Kumar, Thomas M. Moon, Olin Chang, Bryant Chau, Christine Bee, Ishita Barman, Arvind Rajpal, Alan J. Korman, Sean M. West, Pavel Strop, Peter S. Lee
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Antibody engineering
CTLA-4
immune checkpoint
phage display
species cross reactivity
yeast display
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2451296
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2451296

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