Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome
Abstract Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, the complex associations among cognitive deficits in different domains in DLB are largely unknown. To characterize these associations, we investigated and compared the cognitive...
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Nature Portfolio
2025-01-01
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| Online Access: | https://doi.org/10.1038/s41598-024-84946-4 |
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| author | Roraima Yanez-Perez Eloy Garcia-Cabello Annegret Habich Nira Cedres Patricia Diaz-Galvan Carla Abdelnour Jon B. Toledo José Barroso Daniel Ferreira |
| author_facet | Roraima Yanez-Perez Eloy Garcia-Cabello Annegret Habich Nira Cedres Patricia Diaz-Galvan Carla Abdelnour Jon B. Toledo José Barroso Daniel Ferreira |
| author_sort | Roraima Yanez-Perez |
| collection | DOAJ |
| description | Abstract Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, the complex associations among cognitive deficits in different domains in DLB are largely unknown. To characterize these associations, we investigated and compared the cognitive connectome of DLB patients, healthy controls (HC), and Alzheimer’s disease patients (AD). We obtained data from the National Alzheimer’s Coordinating Center. We built cognitive connectomes for DLB (n = 104), HC (n = 3703), and AD (n = 1985) using correlations among 24 cognitive measures mapping multiple cognitive domains. Connectomes were compared using global and nodal graph measures of centrality, integration, and segregation. For global measures, DLB showed a higher global efficiency (integration) and lower transitivity (segregation) than HC and AD. For nodal measures, DLB showed higher global efficiency in most measures, higher participation (centrality) in free-recall memory, processing speed/attention, and executive measures, and lower local efficiency (segregation) than HC. Compared with AD, DLB showed lower nodal strength and local efficiency, especially in memory consolidation. The cognitive connectome of DLB shows a loss of segregation, leading to a loss of cognitive specialization. This study provides the data to advance the understanding of cognitive impairment and clinical phenotype in DLB, with implications for differential diagnosis. |
| format | Article |
| id | doaj-art-ba86cf0880b642c1899c03f93faa2a9d |
| institution | Kabale University |
| issn | 2045-2322 |
| language | English |
| publishDate | 2025-01-01 |
| publisher | Nature Portfolio |
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| spelling | doaj-art-ba86cf0880b642c1899c03f93faa2a9d2025-01-12T12:21:53ZengNature PortfolioScientific Reports2045-23222025-01-0115111110.1038/s41598-024-84946-4Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectomeRoraima Yanez-Perez0Eloy Garcia-Cabello1Annegret Habich2Nira Cedres3Patricia Diaz-Galvan4Carla Abdelnour5Jon B. Toledo6José Barroso7Daniel Ferreira8Division of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska InstitutetDepartment of Psychology, Faculty of Health Sciences, University Fernando Pessoa CanariasDivision of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska InstitutetDivision of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska InstitutetDepartment of Radiology, Mayo ClinicDepartment of Neurology and Neurological Sciences, Stanford University School of MedicineStanley H. Appel Department of Neurology, Nantz National Alzheimer Center, Houston Methodist HospitalDepartment of Psychology, Faculty of Health Sciences, University Fernando Pessoa CanariasDivision of Clinical Geriatrics, Centre for Alzheimer Research, Department of Neurobiology, Care Sciences, and Society, Karolinska InstitutetAbstract Cognition plays a central role in the diagnosis and characterization of dementia with Lewy bodies (DLB). However, the complex associations among cognitive deficits in different domains in DLB are largely unknown. To characterize these associations, we investigated and compared the cognitive connectome of DLB patients, healthy controls (HC), and Alzheimer’s disease patients (AD). We obtained data from the National Alzheimer’s Coordinating Center. We built cognitive connectomes for DLB (n = 104), HC (n = 3703), and AD (n = 1985) using correlations among 24 cognitive measures mapping multiple cognitive domains. Connectomes were compared using global and nodal graph measures of centrality, integration, and segregation. For global measures, DLB showed a higher global efficiency (integration) and lower transitivity (segregation) than HC and AD. For nodal measures, DLB showed higher global efficiency in most measures, higher participation (centrality) in free-recall memory, processing speed/attention, and executive measures, and lower local efficiency (segregation) than HC. Compared with AD, DLB showed lower nodal strength and local efficiency, especially in memory consolidation. The cognitive connectome of DLB shows a loss of segregation, leading to a loss of cognitive specialization. This study provides the data to advance the understanding of cognitive impairment and clinical phenotype in DLB, with implications for differential diagnosis.https://doi.org/10.1038/s41598-024-84946-4CognitionNeurodegenerative diseaseGraph theoryConnectome |
| spellingShingle | Roraima Yanez-Perez Eloy Garcia-Cabello Annegret Habich Nira Cedres Patricia Diaz-Galvan Carla Abdelnour Jon B. Toledo José Barroso Daniel Ferreira Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome Scientific Reports Cognition Neurodegenerative disease Graph theory Connectome |
| title | Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome |
| title_full | Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome |
| title_fullStr | Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome |
| title_full_unstemmed | Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome |
| title_short | Patients with dementia with Lewy bodies display a signature alteration of their cognitive connectome |
| title_sort | patients with dementia with lewy bodies display a signature alteration of their cognitive connectome |
| topic | Cognition Neurodegenerative disease Graph theory Connectome |
| url | https://doi.org/10.1038/s41598-024-84946-4 |
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