Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy

Factor H-related 1 and heparan sulfate architecture contribute to complement dysregulation in C3 glomerulopathy

IntroductionDysregulation of the alternative pathway of complement underlies the pathogenesis of C3 glomerulopathy (C3G). Because Factor H (FH) prevents excessive alternative pathway activity while Factor H-related protein 1 (FHR-1) is believed to enhance this response, we investigated the balance b...

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Main Authors: Amanda K. Slagle, Nicolo Ghiringhelli Borsa, Kai Wang, Amanda O. Taylor, Nicole C. Meyer, Michael B. Jones, William D. Walls, Angela F. M. Nelson, Sarah M. Roberts, Mingyao Sun, Elena Goicoechea de Jorge, Santiago Rodriguez de Cordoba, Diana I. Jalal, Carla M. Nester, Yuzhou Zhang, Richard J. H. Smith
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-05-01
Series:Frontiers in Immunology
Subjects:
Factor H
FHR-1
complement regulation
C3 glomerulopathy
chronic kidney disease
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589674/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1589674/full

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