Analytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab

Analytical development and application of a targeted liquid chromatography-tandem mass spectrometry assay for chimeric aducanumab

A sensitive and specific liquid chromatography-tandem mass spectrometry assay was developed for the quantification of chimeric aducanumab (chAdu), a therapeutic antibody targeting pathological amyloid plaques in Alzheimer’s disease, in murine biological matrices. This method addresses the challenges...

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Bibliographic Details
Main Authors: Emma H. Doud, Kasi Hansen, Kathryn A. Haynes, Kierra Eldridge, Jaison Arrivalagan, Nitin Charbe, Lais Da Silva, Sara K. Quinney, Amber L. Mosley, Stacey J. Sukoff Rizzo, Paul R. Territo
Format: Article
Language:English
Published: Taylor & Francis Group 2025-12-01
Series:mAbs
Subjects:
Aducanumab
5XFAD
PRM
targeted mass spectrometry
biotherapeutic
pharmacokinetics
Online Access:https://www.tandfonline.com/doi/10.1080/19420862.2025.2537118
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https://www.tandfonline.com/doi/10.1080/19420862.2025.2537118

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