Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism
Introduction: Despite the decades long use of [ 11 C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data have been published. Methods: Dosimetry and biodistribution studies were perfor...
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| Format: | Article |
| Language: | English |
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SAGE Publishing
2017-10-01
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| Series: | Molecular Imaging |
| Online Access: | https://doi.org/10.1177/1536012117734485 |
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| author | Nana L. Christensen MLS Steen Jakobsen PhD Anna C. Schacht PhD Ole L. Munk PhD Aage K. O. Alstrup DVM, PhD Lars P. Tolbod PhD Hendrik J. Harms PhD Søren Nielsen MD, PhD Lars C. Gormsen MD, PhD |
| author_facet | Nana L. Christensen MLS Steen Jakobsen PhD Anna C. Schacht PhD Ole L. Munk PhD Aage K. O. Alstrup DVM, PhD Lars P. Tolbod PhD Hendrik J. Harms PhD Søren Nielsen MD, PhD Lars C. Gormsen MD, PhD |
| author_sort | Nana L. Christensen MLS |
| collection | DOAJ |
| description | Introduction: Despite the decades long use of [ 11 C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data have been published. Methods: Dosimetry and biodistribution studies were performed in 2 pigs and 2 healthy volunteers by whole-body [ 11 C]palmitate PET scans. Metabolite studies were performed in 40 participants (healthy and with type 2 diabetes) under basal and hyperinsulinemic conditions. Metabolites were estimated using 2 approaches and subsequently compared: Indirect [ 11 C]CO 2 release and parent [ 11 C]palmitate measured by a solid-phase extraction (SPE) method. Finally, myocardial fatty acid uptake was calculated in a patient cohort using input functions derived from individual metabolite correction compared with population-based metabolite correction. Results: In humans, mean effective dose was 3.23 (0.02) µSv/MBq, with the liver and myocardium receiving the highest absorbed doses. Metabolite correction using only [ 11 C]CO 2 estimates underestimated the fraction of metabolites in studies lasting more than 20 minutes. Population-based metabolite correction showed excellent correlation with individual metabolite correction in the cardiac PET validation cohort. Conclusion: First, mean effective dose of [ 11 C]palmitate is 3.23 (0.02) µSv/MBq in humans allowing multiple scans using ∼300 MBq [ 11 C]palmitate, and secondly, population-based metabolite correction compares well with individual correction. |
| format | Article |
| id | doaj-art-ba6960d54d9d4b1b832a44671c0009a8 |
| institution | Kabale University |
| issn | 1536-0121 |
| language | English |
| publishDate | 2017-10-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Molecular Imaging |
| spelling | doaj-art-ba6960d54d9d4b1b832a44671c0009a82025-01-03T01:22:46ZengSAGE PublishingMolecular Imaging1536-01212017-10-011610.1177/1536012117734485Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid MetabolismNana L. Christensen MLS0Steen Jakobsen PhD1Anna C. Schacht PhD2Ole L. Munk PhD3Aage K. O. Alstrup DVM, PhD4Lars P. Tolbod PhD5Hendrik J. Harms PhD6Søren Nielsen MD, PhD7Lars C. Gormsen MD, PhD8 Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, Denmark Department of Endocrinology, Aarhus University Hospital, Aarhus C, Denmark Department of Nuclear Medicine & PET Centre, Aarhus University Hospital, Aarhus C, DenmarkIntroduction: Despite the decades long use of [ 11 C]palmitate positron emission tomography (PET)/computed tomography in basic metabolism studies, only personal communications regarding dosimetry and biodistribution data have been published. Methods: Dosimetry and biodistribution studies were performed in 2 pigs and 2 healthy volunteers by whole-body [ 11 C]palmitate PET scans. Metabolite studies were performed in 40 participants (healthy and with type 2 diabetes) under basal and hyperinsulinemic conditions. Metabolites were estimated using 2 approaches and subsequently compared: Indirect [ 11 C]CO 2 release and parent [ 11 C]palmitate measured by a solid-phase extraction (SPE) method. Finally, myocardial fatty acid uptake was calculated in a patient cohort using input functions derived from individual metabolite correction compared with population-based metabolite correction. Results: In humans, mean effective dose was 3.23 (0.02) µSv/MBq, with the liver and myocardium receiving the highest absorbed doses. Metabolite correction using only [ 11 C]CO 2 estimates underestimated the fraction of metabolites in studies lasting more than 20 minutes. Population-based metabolite correction showed excellent correlation with individual metabolite correction in the cardiac PET validation cohort. Conclusion: First, mean effective dose of [ 11 C]palmitate is 3.23 (0.02) µSv/MBq in humans allowing multiple scans using ∼300 MBq [ 11 C]palmitate, and secondly, population-based metabolite correction compares well with individual correction.https://doi.org/10.1177/1536012117734485 |
| spellingShingle | Nana L. Christensen MLS Steen Jakobsen PhD Anna C. Schacht PhD Ole L. Munk PhD Aage K. O. Alstrup DVM, PhD Lars P. Tolbod PhD Hendrik J. Harms PhD Søren Nielsen MD, PhD Lars C. Gormsen MD, PhD Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism Molecular Imaging |
| title | Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism |
| title_full | Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism |
| title_fullStr | Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism |
| title_full_unstemmed | Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism |
| title_short | Whole-Body Biodistribution, Dosimetry, and Metabolite Correction of [C]Palmitate: A PET Tracer for Imaging of Fatty Acid Metabolism |
| title_sort | whole body biodistribution dosimetry and metabolite correction of c palmitate a pet tracer for imaging of fatty acid metabolism |
| url | https://doi.org/10.1177/1536012117734485 |
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