The Development of Al<sup>18</sup>F-NOTA-FAP-2286 as an FAP-Targeted PET Tracer and the Translational Application in the Diagnosis of Acquired Drug Resistance in Progressive Prostate Cancer

The Development of Al<sup>18</sup>F-NOTA-FAP-2286 as an FAP-Targeted PET Tracer and the Translational Application in the Diagnosis of Acquired Drug Resistance in Progressive Prostate Cancer

<b>Objectives</b>: Tumor heterogeneity and acquired resistance to prostate-specific membrane antigen (PSMA) radioligand therapy (PRLT) pose significant challenges to PSMA PET-based diagnosis. This study aimed to develop an Al<sup>18</sup>F-labeled FAP-targeted tracer and expl...

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Bibliographic Details
Main Authors: Xia Du, Yu Zhang, Yao Jia, Bo Gao
Format: Article
Language:English
Published: MDPI AG 2025-04-01
Series:Pharmaceutics
Subjects:
fibroblast activation protein-α
pre-chelation
tumor heterogeneity
Al<sup>18</sup>F-NOTA-FAP-2286
prostate cancer
acquired resistance
Online Access:https://www.mdpi.com/1999-4923/17/5/552
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