Preclinical characterisation of changes in cardiac function and circulating biomarkers following differential irradiation of thoracic volumes

Preclinical characterisation of changes in cardiac function and circulating biomarkers following differential irradiation of thoracic volumes

IntroductionThe heart and lungs are critical organs at risk in patients receiving radiotherapy for thoracic tumours. Preclinical studies in rat models have provided evidence indicating consequential effects of lung radiation on the heart through vascular remodelling which leads to pulmonary arterial...

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Main Authors: Refik Kuburas, Mihaela Ghita-Pettigrew, Gerard M. Walls, Brianna N. Kerr, Kathryn H. Brown, Cecilia Facchi, Alan McWilliam, Marcel van Herk, Kaye J. Williams, Karl T. Butterworth
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Oncology
Subjects:
radiotherapy
preclinical model
cardiotoxicity
heart irradiation
lung irradiation
cardio-pulmonary
Online Access:https://www.frontiersin.org/articles/10.3389/fonc.2025.1623753/full
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https://www.frontiersin.org/articles/10.3389/fonc.2025.1623753/full

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