Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility

Integrative analyses reveal signaling pathways underlying familial breast cancer susceptibility

Abstract The signaling events that drive familial breast cancer (FBC) risk remain poorly understood. While the majority of genomic studies have focused on genetic risk variants, known risk variants account for at most 30% of FBC cases. Considering that multiple genes may influence FBC risk, we hypot...

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Main Authors: Stephen R Piccolo, Laura M Hoffman, Thomas Conner, Gajendra Shrestha, Adam L Cohen, Jeffrey R Marks, Leigh A Neumayer, Cori A Agarwal, Mary C Beckerle, Irene L Andrulis, Avrum E Spira, Philip J Moos, Saundra S Buys, William Evan Johnson, Andrea H Bild
Format: Article
Language:English
Published: Springer Nature 2016-03-01
Series:Molecular Systems Biology
Subjects:
breast cancer
cellular adhesion
disease susceptibility
multiomic analysis, signaling pathways
Online Access:https://doi.org/10.15252/msb.20156506
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https://doi.org/10.15252/msb.20156506

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