The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss
Background Female pattern hair loss (FPHL) is a disease characterized by progressive hair thinning. Topical minoxidil is an FDA-approved drug for the treatment of androgenetic alopecia. Dutasteride (a 5α-reductase inhibitor) can also be used in a topical form to reduce its systemic side effects. Bot...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2024-01-01
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| Series: | Journal of the Egyptian Women’s Dermatologic Society |
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| Online Access: | https://journals.lww.com/10.4103/jewd.jewd_35_23 |
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| author | Reham Essam Heba Selim Rana Ehab |
| author_facet | Reham Essam Heba Selim Rana Ehab |
| author_sort | Reham Essam |
| collection | DOAJ |
| description | Background
Female pattern hair loss (FPHL) is a disease characterized by progressive hair thinning. Topical minoxidil is an FDA-approved drug for the treatment of androgenetic alopecia. Dutasteride (a 5α-reductase inhibitor) can also be used in a topical form to reduce its systemic side effects. Both agents can be used as mesotherapy after microneedling of the scalp to enhance their potency in the treatment of FPHL.
Objective
To compare the use of combined minoxidil and dutasteride versus dutasteride alone when applied topically after microneedling of the scalp in the treatment of FPHL.
Patients and methods
This study included 40 female patients with FPHL. Patients were divided into two groups: one group was treated with combined minoxidil 0.1% and dutasteride 0.01% with microneedling, and the other group received dutasteride 0.01% alone with microneedling. Trichoscopic evaluation was done.
Results
In a group A, who were treated with combined minoxidil and dutasteride, 4 patients (20%) had excellent improvement, 10 patients (50%) had a good response, 5 patients (25%) had a moderate response, and only 1 patient (5%) had no response, while in a group B, who treated with dutasteride, 1 patient (5%) had excellent improvement, 4 patients (20%) had a good response, 10 patients (50%) had a moderate response, and 5patients(25%) had no response, with a significant difference between both groups (P=0.033. There were the nonsignificant difference between both groups regarding trichoscopic findings before treatment, but after treatment, there was a significant difference between both groups concerning the mean percentage of the follicular unit with one hair and the number of patients who had vellus hairs in the dermoscopic field.
Conclusion
The combination of minoxidil 0.1% and dutasteride 0.01% after microneedling of the scalp was significantly more effective than dutasteride alone with microneedling for the treatment of FPHL. |
| format | Article |
| id | doaj-art-b9ef85f5674641ddb10c5fd6b351a4ff |
| institution | Kabale University |
| issn | 2090-2565 |
| language | English |
| publishDate | 2024-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Journal of the Egyptian Women’s Dermatologic Society |
| spelling | doaj-art-b9ef85f5674641ddb10c5fd6b351a4ff2025-01-04T14:14:12ZengWolters Kluwer Medknow PublicationsJournal of the Egyptian Women’s Dermatologic Society2090-25652024-01-01211293510.4103/jewd.jewd_35_23The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair lossReham EssamHeba SelimRana EhabBackground Female pattern hair loss (FPHL) is a disease characterized by progressive hair thinning. Topical minoxidil is an FDA-approved drug for the treatment of androgenetic alopecia. Dutasteride (a 5α-reductase inhibitor) can also be used in a topical form to reduce its systemic side effects. Both agents can be used as mesotherapy after microneedling of the scalp to enhance their potency in the treatment of FPHL. Objective To compare the use of combined minoxidil and dutasteride versus dutasteride alone when applied topically after microneedling of the scalp in the treatment of FPHL. Patients and methods This study included 40 female patients with FPHL. Patients were divided into two groups: one group was treated with combined minoxidil 0.1% and dutasteride 0.01% with microneedling, and the other group received dutasteride 0.01% alone with microneedling. Trichoscopic evaluation was done. Results In a group A, who were treated with combined minoxidil and dutasteride, 4 patients (20%) had excellent improvement, 10 patients (50%) had a good response, 5 patients (25%) had a moderate response, and only 1 patient (5%) had no response, while in a group B, who treated with dutasteride, 1 patient (5%) had excellent improvement, 4 patients (20%) had a good response, 10 patients (50%) had a moderate response, and 5patients(25%) had no response, with a significant difference between both groups (P=0.033. There were the nonsignificant difference between both groups regarding trichoscopic findings before treatment, but after treatment, there was a significant difference between both groups concerning the mean percentage of the follicular unit with one hair and the number of patients who had vellus hairs in the dermoscopic field. Conclusion The combination of minoxidil 0.1% and dutasteride 0.01% after microneedling of the scalp was significantly more effective than dutasteride alone with microneedling for the treatment of FPHL.https://journals.lww.com/10.4103/jewd.jewd_35_23dutasteridefemale pattern hair lossmicroneedlingminoxidiltrichoscopy |
| spellingShingle | Reham Essam Heba Selim Rana Ehab The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss Journal of the Egyptian Women’s Dermatologic Society dutasteride female pattern hair loss microneedling minoxidil trichoscopy |
| title | The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss |
| title_full | The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss |
| title_fullStr | The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss |
| title_full_unstemmed | The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss |
| title_short | The boosting effect of minoxidil 0.1% when combined with dutasteride 0.01% and microneedling in the treatment of female pattern hair loss |
| title_sort | boosting effect of minoxidil 0 1 when combined with dutasteride 0 01 and microneedling in the treatment of female pattern hair loss |
| topic | dutasteride female pattern hair loss microneedling minoxidil trichoscopy |
| url | https://journals.lww.com/10.4103/jewd.jewd_35_23 |
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