Choosing an Animal Model for the Study of Functional Dyspepsia
Functional dyspepsia (FD) is a common functional gastrointestinal disorder with pain or discomfort in the upper abdomen as the main characteristic. The prevalence of FD worldwide varies between 5% and 11%. This condition adversely affects attendance and productivity in the workplace. Emerging eviden...
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| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Wiley
2018-01-01
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| Series: | Canadian Journal of Gastroenterology and Hepatology |
| Online Access: | http://dx.doi.org/10.1155/2018/1531958 |
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| _version_ | 1832558129082007552 |
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| author | Yang Ye Xue-Rui Wang Yang Zheng Jing-Wen Yang Na-Na Yang Guang-Xia Shi Cun-Zhi Liu |
| author_facet | Yang Ye Xue-Rui Wang Yang Zheng Jing-Wen Yang Na-Na Yang Guang-Xia Shi Cun-Zhi Liu |
| author_sort | Yang Ye |
| collection | DOAJ |
| description | Functional dyspepsia (FD) is a common functional gastrointestinal disorder with pain or discomfort in the upper abdomen as the main characteristic. The prevalence of FD worldwide varies between 5% and 11%. This condition adversely affects attendance and productivity in the workplace. Emerging evidence is beginning to unravel the pathophysiologies of FD, and new data on treatment are helping to guide evidence-based practice. In order to better understand the pathophysiologies of FD and explore better treatment options, various kinds of animal models of FD have been developed. However, it is unclear which of these models most closely mimic the human disease. This review provides a comprehensive overview of the currently available animal models of FD in relationship to the clinical features of the disease. The rationales, methods, merits, and disadvantages for modelling specific symptoms of FD are discussed in detail. |
| format | Article |
| id | doaj-art-b9e1d1dce04f4b5a958e5766fd637356 |
| institution | Kabale University |
| issn | 2291-2789 2291-2797 |
| language | English |
| publishDate | 2018-01-01 |
| publisher | Wiley |
| record_format | Article |
| series | Canadian Journal of Gastroenterology and Hepatology |
| spelling | doaj-art-b9e1d1dce04f4b5a958e5766fd6373562025-02-03T01:33:16ZengWileyCanadian Journal of Gastroenterology and Hepatology2291-27892291-27972018-01-01201810.1155/2018/15319581531958Choosing an Animal Model for the Study of Functional DyspepsiaYang Ye0Xue-Rui Wang1Yang Zheng2Jing-Wen Yang3Na-Na Yang4Guang-Xia Shi5Cun-Zhi Liu6Acupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaAcupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaAcupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaAcupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaAcupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaAcupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaAcupuncture and Moxibustion Department, Beijing Hospital of Traditional Chinese Medicine Affiliated to Capital Medical University, Beijing Key Laboratory of Acupuncture Neuromodulation, Beijing, ChinaFunctional dyspepsia (FD) is a common functional gastrointestinal disorder with pain or discomfort in the upper abdomen as the main characteristic. The prevalence of FD worldwide varies between 5% and 11%. This condition adversely affects attendance and productivity in the workplace. Emerging evidence is beginning to unravel the pathophysiologies of FD, and new data on treatment are helping to guide evidence-based practice. In order to better understand the pathophysiologies of FD and explore better treatment options, various kinds of animal models of FD have been developed. However, it is unclear which of these models most closely mimic the human disease. This review provides a comprehensive overview of the currently available animal models of FD in relationship to the clinical features of the disease. The rationales, methods, merits, and disadvantages for modelling specific symptoms of FD are discussed in detail.http://dx.doi.org/10.1155/2018/1531958 |
| spellingShingle | Yang Ye Xue-Rui Wang Yang Zheng Jing-Wen Yang Na-Na Yang Guang-Xia Shi Cun-Zhi Liu Choosing an Animal Model for the Study of Functional Dyspepsia Canadian Journal of Gastroenterology and Hepatology |
| title | Choosing an Animal Model for the Study of Functional Dyspepsia |
| title_full | Choosing an Animal Model for the Study of Functional Dyspepsia |
| title_fullStr | Choosing an Animal Model for the Study of Functional Dyspepsia |
| title_full_unstemmed | Choosing an Animal Model for the Study of Functional Dyspepsia |
| title_short | Choosing an Animal Model for the Study of Functional Dyspepsia |
| title_sort | choosing an animal model for the study of functional dyspepsia |
| url | http://dx.doi.org/10.1155/2018/1531958 |
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