Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

Ten‐Eleven Translocation Family Proteins: Structure, Biological Functions, Diseases, and Targeted Therapy

ABSTRACT Ten‐eleven translocation (TET) family proteins are Fe(II)‐ and α‐ketoglutarate‐dependent dioxygenases, comprising three family members: TET1, TET2, and TET3. These enzymes drive DNA demethylation by sequentially oxidizing 5‐methylcytosine to 5‐hydroxymethylcytosine, 5‐formylcytosine, and 5‐...

Full description

Saved in:
Bibliographic Details
Main Authors: Junzhi Liang, Xinni Na, Lingbo Meng, Lixia He, Ting Shu, Yuanyuan Fang, Bowen Zhang, Zhongyu Zhao, Cuishan Guo, Tingting Li, Zhijing Na, Da Li, Xue Xiao
Format: Article
Language:English
Published: Wiley 2025-07-01
Series:MedComm
Subjects:
Biological functions
Demethylation
Diseases
Ten‐eleven translocation
Therapeutic strategies
Online Access:https://doi.org/10.1002/mco2.70245
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

https://doi.org/10.1002/mco2.70245

Similar Items