Constitutive activity of the inhibitory G protein pathway mediated by non-visual opsin Opn7b reduces cFos activity in stress and fear circuits and modulates avoidance behavior

Constitutive activity of the inhibitory G protein pathway mediated by non-visual opsin Opn7b reduces cFos activity in stress and fear circuits and modulates avoidance behavior

Constitutive activity of G protein-coupled receptors (GPCRs) plays an important role in brain function and disease including neurodegenerative and psychiatric disorders. The non-visual opsin Opn7b is a constitutively active Gi/o coupled GPCR which has been used to synchronize neuronal networks. Here...

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Bibliographic Details
Main Authors: Hanna Böke, Hannah Schulte, Maria Worm, Julia Bihorac, Brix Mücher, Martin Hadamitzky, Ida Siveke, Stefan Herlitze, Katharina Spoida
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-06-01
Series:Frontiers in Behavioral Neuroscience
Subjects:
VTA (ventral tegmental area)
GPCR (G protein coupled receptor)
optogenetics
BNST (bed nucleus of the stria terminalis)
cFos
constitutive activity of GPCRs
Online Access:https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1540947/full
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https://www.frontiersin.org/articles/10.3389/fnbeh.2025.1540947/full

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