Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery
Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing and drug delivery, achieve enhanced functionality when combined wit...
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| Format: | Article |
| Language: | English |
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Elsevier
2025-04-01
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| Series: | Materials Today Bio |
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| Online Access: | http://www.sciencedirect.com/science/article/pii/S2590006425000626 |
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| author | Gaobo Wang Natsuho Moriyama Soichiro Tottori Matsuhiko Nishizawa |
| author_facet | Gaobo Wang Natsuho Moriyama Soichiro Tottori Matsuhiko Nishizawa |
| author_sort | Gaobo Wang |
| collection | DOAJ |
| description | Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing and drug delivery, achieve enhanced functionality when combined with iontophoresis. Iontophoresis-assisted microneedles have emerged as an innovative solution, enabling real-time biosensing and precise drug delivery within closed-loop systems. These integrated platforms represent a major advancement in personalized medicine, allowing dynamic therapeutic adjustments based on continuous feedback. This review highlights the latest developments in iontophoresis-assisted microneedles for transdermal biosensing, drug delivery, and closed-loop applications. It delves into the mechanisms of iontophoresis, assesses its advantages and limitations, and explores future directions for these transformative technologies. |
| format | Article |
| id | doaj-art-b9bb58218ac14f10a6933b3df81809a7 |
| institution | Kabale University |
| issn | 2590-0064 |
| language | English |
| publishDate | 2025-04-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Materials Today Bio |
| spelling | doaj-art-b9bb58218ac14f10a6933b3df81809a72025-01-23T05:27:38ZengElsevierMaterials Today Bio2590-00642025-04-0131101504Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug deliveryGaobo Wang0Natsuho Moriyama1Soichiro Tottori2Matsuhiko Nishizawa3Department of Biomedical Engineering, School of Medical Engineering, Xinxiang Medical University, Xinxiang, 453003, China; Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-1 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, JapanDepartment of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-4 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, JapanDepartment of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-1 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, JapanDepartment of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-1 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, Japan; Department of Biomedical Engineering, Graduate School of Biomedical Engineering, Tohoku University, 6-6-4 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, Japan; Corresponding author. Department of Finemechanics, Graduate School of Engineering, Tohoku University, 6-6-1 Aramaki Aoba, Aoba-ku, Sendai, 980-8579, Japan.Integrating advanced manufacturing techniques and nanotechnology with cutting-edge materials has driven significant progress in global healthcare. Microneedles, recognized for their minimally invasive approach to transdermal sensing and drug delivery, achieve enhanced functionality when combined with iontophoresis. Iontophoresis-assisted microneedles have emerged as an innovative solution, enabling real-time biosensing and precise drug delivery within closed-loop systems. These integrated platforms represent a major advancement in personalized medicine, allowing dynamic therapeutic adjustments based on continuous feedback. This review highlights the latest developments in iontophoresis-assisted microneedles for transdermal biosensing, drug delivery, and closed-loop applications. It delves into the mechanisms of iontophoresis, assesses its advantages and limitations, and explores future directions for these transformative technologies.http://www.sciencedirect.com/science/article/pii/S2590006425000626IontophoresisMicroneedleTransdermal sensingDrug deliveryClosed-loop system |
| spellingShingle | Gaobo Wang Natsuho Moriyama Soichiro Tottori Matsuhiko Nishizawa Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery Materials Today Bio Iontophoresis Microneedle Transdermal sensing Drug delivery Closed-loop system |
| title | Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery |
| title_full | Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery |
| title_fullStr | Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery |
| title_full_unstemmed | Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery |
| title_short | Recent advances in iontophoresis-assisted microneedle devices for transdermal biosensing and drug delivery |
| title_sort | recent advances in iontophoresis assisted microneedle devices for transdermal biosensing and drug delivery |
| topic | Iontophoresis Microneedle Transdermal sensing Drug delivery Closed-loop system |
| url | http://www.sciencedirect.com/science/article/pii/S2590006425000626 |
| work_keys_str_mv | AT gaobowang recentadvancesiniontophoresisassistedmicroneedledevicesfortransdermalbiosensinganddrugdelivery AT natsuhomoriyama recentadvancesiniontophoresisassistedmicroneedledevicesfortransdermalbiosensinganddrugdelivery AT soichirotottori recentadvancesiniontophoresisassistedmicroneedledevicesfortransdermalbiosensinganddrugdelivery AT matsuhikonishizawa recentadvancesiniontophoresisassistedmicroneedledevicesfortransdermalbiosensinganddrugdelivery |