Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors

Generation of chimeric antigen receptor T cells targeting p95HER2 in solid tumors

Abstract The redirection of T lymphocytes against tumor-associated or tumor-specific antigens, using bispecific antibodies or chimeric antigen receptors (CAR), has shown therapeutic success against certain hematological malignancies. However, this strategy has not been effective against solid tumors...

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Main Authors: Macarena Román Alonso, Ariadna Grinyó-Escuer, Santiago Duro-Sánchez, Irene Rius-Ruiz, Marta Bort-Brusca, Marta Escorihuela, Susana Maqueda-Marcos, Sandra Pérez-Ramos, Judit Gago, Vanesa Nogales, Martín Espinosa-Bravo, Vicente Peg, Santiago Escrivá-de-Romaní, Laia Foradada, Laura Soucek, Irene Braña, Vladimir Galvao, Silvia Martín-Lluesma, Ekkehard Moessner, Christian Klein, Elena Garralda, Cristina Saura, Joaquín Arribas
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-53265-7
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https://doi.org/10.1038/s41467-024-53265-7

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