Human adaptation and diversification in the Microsporum canis complex
Abstract The Microsporum canis complex consists of one zoophilic species, M. canis, and two anthropophilic species, M. audouinii and M. ferrugineum. These species are the most widespread zoonotic pathogens causing dermatophytosis in cats and humans worldwide. To clarify the evolutionary relationship...
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| Language: | English |
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BMC
2023-07-01
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| Series: | IMA Fungus |
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| Online Access: | https://doi.org/10.1186/s43008-023-00120-x |
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| author | Xin Zhou Sarah A. Ahmed Chao Tang Maria Eduarda Grisolia José Francisco Ghignatti Warth Kristen Webster Andrea Peano Silke Uhrlass Claudia Cafarchia Marie Pierre Hayette Rosalie Sacheli Tadeja Matos Yingqian Kang G. Sybren de Hoog Peiying Feng |
| author_facet | Xin Zhou Sarah A. Ahmed Chao Tang Maria Eduarda Grisolia José Francisco Ghignatti Warth Kristen Webster Andrea Peano Silke Uhrlass Claudia Cafarchia Marie Pierre Hayette Rosalie Sacheli Tadeja Matos Yingqian Kang G. Sybren de Hoog Peiying Feng |
| author_sort | Xin Zhou |
| collection | DOAJ |
| description | Abstract The Microsporum canis complex consists of one zoophilic species, M. canis, and two anthropophilic species, M. audouinii and M. ferrugineum. These species are the most widespread zoonotic pathogens causing dermatophytosis in cats and humans worldwide. To clarify the evolutionary relationship between the three species and explore the potential host shift process, this study used phylogenetic analysis, population structure analysis, multispecies coalescent analyses, determination of MAT idiomorph distribution, sexual crosses, and macromorphology and physicochemical features to address the above questions. The complex of Microsporum canis, M. audouinii and M. ferrugineum comprises 12 genotypes. MAT1-1 was present only in M. canis, while the anthropophilic entities contained MAT1-2. The pseudocleistothecia were yielded by the mating behaviour of M. canis and M. audouinii. Growth rates and lipase, keratinolysis and urea hydrolytic capacities of zoophilic M. canis isolates were all higher than those of anthropophilic strains; DNase activity of M. ferrugineum exceeded that of M. canis. The optimum growth temperature was 28 °C, but 22 °C favoured the development of macroconidia. Molecular data, physicochemical properties and phenotypes suggest the adaptation of zoophilic M. canis to anthropophilic M. ferrugineum, with M. audouinii in an intermediate position. |
| format | Article |
| id | doaj-art-b9acf21d3d634049b2b1845c4c7caa22 |
| institution | Kabale University |
| issn | 2210-6359 |
| language | English |
| publishDate | 2023-07-01 |
| publisher | BMC |
| record_format | Article |
| series | IMA Fungus |
| spelling | doaj-art-b9acf21d3d634049b2b1845c4c7caa222025-02-03T01:32:48ZengBMCIMA Fungus2210-63592023-07-0114111510.1186/s43008-023-00120-xHuman adaptation and diversification in the Microsporum canis complexXin Zhou0Sarah A. Ahmed1Chao Tang2Maria Eduarda Grisolia3José Francisco Ghignatti Warth4Kristen Webster5Andrea Peano6Silke Uhrlass7Claudia Cafarchia8Marie Pierre Hayette9Rosalie Sacheli10Tadeja Matos11Yingqian Kang12G. Sybren de Hoog13Peiying Feng14Center of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina HospitalCenter of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina HospitalCenter of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina HospitalBioprocess Engineering and Biotechnology, Federal University of ParanáMicrobiology, Parasitology and Pathology Graduate Program, Federal University of ParanáDepartment of Dermatology, Center for Medical Mycology, University HospitalsDepartment of Veterinary Sciences, University of TurinLabor für Medizinische Mikrobiologie Nenoff / KrügerDepartment of Veterinary Medicine, University of Bari Aldo MoroBelgian National Reference Center, Clinical Microbiology, University Hospital of LiegeBelgian National Reference Center, Clinical Microbiology, University Hospital of LiegeMedical Faculty, Institute of Microbiology and Immunology, University of LjubljanaKey Laboratory of Environmental Pollution Monitoring and Disease Control, Ministry of Education of Guizhou & Guizhou Talent Base for Microbiology and Human Health, School of Basic Medical Sciences, Key Laboratory of Microbiology and Parasitology of Education Department of Guizhou, Guizhou Medical UniversityCenter of Expertise in Mycology of Radboud University Medical Center, Canisius Wilhelmina HospitalDepartment of Dermatology, 3rd Affiliated Hospital, Sun Yat-senen UniversityAbstract The Microsporum canis complex consists of one zoophilic species, M. canis, and two anthropophilic species, M. audouinii and M. ferrugineum. These species are the most widespread zoonotic pathogens causing dermatophytosis in cats and humans worldwide. To clarify the evolutionary relationship between the three species and explore the potential host shift process, this study used phylogenetic analysis, population structure analysis, multispecies coalescent analyses, determination of MAT idiomorph distribution, sexual crosses, and macromorphology and physicochemical features to address the above questions. The complex of Microsporum canis, M. audouinii and M. ferrugineum comprises 12 genotypes. MAT1-1 was present only in M. canis, while the anthropophilic entities contained MAT1-2. The pseudocleistothecia were yielded by the mating behaviour of M. canis and M. audouinii. Growth rates and lipase, keratinolysis and urea hydrolytic capacities of zoophilic M. canis isolates were all higher than those of anthropophilic strains; DNase activity of M. ferrugineum exceeded that of M. canis. The optimum growth temperature was 28 °C, but 22 °C favoured the development of macroconidia. Molecular data, physicochemical properties and phenotypes suggest the adaptation of zoophilic M. canis to anthropophilic M. ferrugineum, with M. audouinii in an intermediate position.https://doi.org/10.1186/s43008-023-00120-xDermatophytesHost shiftPhylogenyMAT idiomorph distributionPhysicochemical featuresTinea capitis |
| spellingShingle | Xin Zhou Sarah A. Ahmed Chao Tang Maria Eduarda Grisolia José Francisco Ghignatti Warth Kristen Webster Andrea Peano Silke Uhrlass Claudia Cafarchia Marie Pierre Hayette Rosalie Sacheli Tadeja Matos Yingqian Kang G. Sybren de Hoog Peiying Feng Human adaptation and diversification in the Microsporum canis complex IMA Fungus Dermatophytes Host shift Phylogeny MAT idiomorph distribution Physicochemical features Tinea capitis |
| title | Human adaptation and diversification in the Microsporum canis complex |
| title_full | Human adaptation and diversification in the Microsporum canis complex |
| title_fullStr | Human adaptation and diversification in the Microsporum canis complex |
| title_full_unstemmed | Human adaptation and diversification in the Microsporum canis complex |
| title_short | Human adaptation and diversification in the Microsporum canis complex |
| title_sort | human adaptation and diversification in the microsporum canis complex |
| topic | Dermatophytes Host shift Phylogeny MAT idiomorph distribution Physicochemical features Tinea capitis |
| url | https://doi.org/10.1186/s43008-023-00120-x |
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