Formulation development of a stable influenza recombinant neuraminidase vaccine candidate

Formulation development of a stable influenza recombinant neuraminidase vaccine candidate

Current influenza vaccines could be augmented by including recombinant neuraminidase (rNA) protein antigen to broaden protective immunity and improve efficacy. Toward this goal, we investigated formulation conditions to optimize rNA physicochemical stability. When rNA in sodium phosphate saline buff...

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Bibliographic Details
Main Authors: Bing Li, Irina V. Ustyugova, Lisa Szymkowicz, Shaolong Zhu, Marin Ming, Karen Y. Y. Fung, Guadalupe Cortés, D. Andrew James, Michael Hrynyk, Nausheen Rahman, Roger H. Brookes, Salvador F. Ausar
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Human Vaccines & Immunotherapeutics
Subjects:
Vaccine
neuraminidase
freezing/thawing
recombinant
CQA
antigenicity
Online Access:https://www.tandfonline.com/doi/10.1080/21645515.2024.2304393
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https://www.tandfonline.com/doi/10.1080/21645515.2024.2304393

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