Chalkophore-mediated respiratory oxidase flexibility controls M. tuberculosis virulence

Oxidative phosphorylation has emerged as a critical therapeutic vulnerability of M. tuberculosis (Mtb). However, it is unknown how intracellular bacterial pathogens such as Mtb maintain respiration during infection despite the chemical effectors of host immunity. Mtb synthesizes diisonitrile lipopep...

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Bibliographic Details
Main Authors: John A Buglino, Yaprak Ozakman, Chad E Hatch, Anna Benjamin, Derek S Tan, Michael S Glickman
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2025-06-01
Series:eLife
Subjects:
Online Access:https://elifesciences.org/articles/105794
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