A reappraisal of cell cycle phase enrichment in synchronized estrogen receptor-positive cell models derived from breast adenocarcinomas

A reappraisal of cell cycle phase enrichment in synchronized estrogen receptor-positive cell models derived from breast adenocarcinomas

Abstract 17β-estradiol (E2), the main circulating estrogen hormone, is a critical signaling factor for the growth, differentiation, and function of breast epithelial cells. The effects of E2 on the breast tissue are primarily mediated by the estrogen receptor α (ERα). Deregulation of the E2-ERα sign...

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Bibliographic Details
Main Authors: Pelin Toker, Hazal Ayten, Öykü Deniz Demiralay, Büşra Bınarcı, Gizem Turan, Çağla Ece Olgun, Pelin Yaşar, Hesna Begüm Akman, Mesut Muyan
Format: Article
Language:English
Published: Nature Portfolio 2025-02-01
Series:Scientific Reports
Subjects:
Breast cancer
Cell cycle
Estrogen
Synchronization
Online Access:https://doi.org/10.1038/s41598-025-90456-8
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https://doi.org/10.1038/s41598-025-90456-8

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