The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

The nutrient-sensing Rag-GTPase complex in B cells controls humoral immunity via TFEB/TFE3-dependent mitochondrial fitness

Abstract Germinal center (GC) formation, which is an integrant part of humoral immunity, involves energy-consuming metabolic reprogramming. Rag-GTPases are known to signal amino acid availability to cellular pathways that regulate nutrient distribution such as the mechanistic target of rapamycin com...

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Main Authors: Xingxing Zhu, Yue Wu, Yanfeng Li, Xian Zhou, Jens O. Watzlawik, Yin Maggie Chen, Ariel L. Raybuck, Daniel D. Billadeau, Virginia Smith Shapiro, Wolfdieter Springer, Jie Sun, Mark R. Boothby, Hu Zeng
Format: Article
Language:English
Published: Nature Portfolio 2024-11-01
Series:Nature Communications
Online Access:https://doi.org/10.1038/s41467-024-54344-5
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https://doi.org/10.1038/s41467-024-54344-5

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