Peroxiredoxin 1 promotes intestinal inflammation by activating the NLRP3 inflammasome in macrophages through lysosomal disruption in Crohn’s disease

Peroxiredoxin 1 promotes intestinal inflammation by activating the NLRP3 inflammasome in macrophages through lysosomal disruption in Crohn’s disease

Abstract Damage-associated molecular patterns (DAMPs) are a cause of Crohn’s disease (CD). Peroxiredoxin 1 (Prdx1), a newly identified DAMP, plays a critical role in organ injury with its potent proinflammatory properties. However, its specific role in CD remains unclear. Here, we identify serum Prd...

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Main Authors: Shenglan Li, Qiuping Xia, Ying He, Wei Wu, Damu Tang, Zhenghao Deng, Zhijun Zeng, Sha Tu, Bo Chen, Lei Gu, Xinyi Yang, Yu Peng, Huixiang Yang, Zhangzhe Peng
Format: Article
Language:English
Published: Nature Publishing Group 2025-07-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-025-07898-1
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https://doi.org/10.1038/s41419-025-07898-1

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