Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart

Impaired autophagy flux contributes to enhanced ischemia reperfusion injury in the diabetic heart

Myocardial ischemia/reperfusion (I/R) injury is exacerbated in diabetic individuals and animal models. We tested whether autophagy is an important cellular determinant of cell death. First, we utilized a cellular model of hypoxia reoxygenation (H/R) in H9c2 cells cultured in low or high glucose (HG)...

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Bibliographic Details
Main Authors: Jialing Tang, Nanyoung Yoon, Keith Dadson, Hye Kyoung Sung, Yubin Lei, Thanh Q. Dang, Wing Yan Chung, Saher Ahmed, Ali A. Abdul-Sater, Jun Wu, Ren-Ke Li, James Jonkman, Trevor McKee, Justin Grant, Jeffrey D. Peterson, Gary Sweeney
Format: Article
Language:English
Published: Taylor & Francis Group 2024-12-01
Series:Autophagy Reports
Subjects:
Autophagy
cardiac remodeling
cathepsin
diabetes
fluorescence molecular tomography
ischemia-reperfusion
Online Access:https://www.tandfonline.com/doi/10.1080/27694127.2024.2330327
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https://www.tandfonline.com/doi/10.1080/27694127.2024.2330327

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