Reconstructed Epidermis Produced with Atopic Dog Keratinocytes Only Exhibit Skin Barrier Defects after the Addition of Proinflammatory and Allergic Cytokines

Reconstructed Epidermis Produced with Atopic Dog Keratinocytes Only Exhibit Skin Barrier Defects after the Addition of Proinflammatory and Allergic Cytokines

Our objectives were to explore epidermal barrier defects in dogs with atopic dermatitis and to determine whether the defects are genetically determined or secondary to skin inflammation. First, the expression of filaggrin, corneodesmosin, and claudin1, analyzed using indirect immunofluorescence in s...

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Bibliographic Details
Main Authors: Daniel Combarros, Rahma Brahmi, Emma Musaefendic, Alizée Heit, Jevgenija Kondratjeva, Fabien Moog, Charline Pressanti, Line A. Lecru, Sabine Arbouille, Catherine Laffort, Dominique Goudounèche, Jessie Brun, Michel Simon, Marie-Christine Cadiergues
Format: Article
Language:English
Published: Elsevier 2025-03-01
Series:JID Innovations
Subjects:
Atopic dermatitis
Dog
Inflammation
Model
Skin barrier
Online Access:http://www.sciencedirect.com/science/article/pii/S266702672400078X
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