Pediatric Orally Disintegrating Tablets (ODTs) with Enhanced Palatability Based on Propranolol HCl Coground with Hydroxypropyl-β-Cyclodextrin

Pediatric Orally Disintegrating Tablets (ODTs) with Enhanced Palatability Based on Propranolol HCl Coground with Hydroxypropyl-β-Cyclodextrin

Background: Propranolol, largely prescribed as an antihypertensive and antiarrhythmic drug in pediatrics, is characterized by a bitter taste and an astringent aftertaste. Currently, the therapy requires crushing of tablets for adults and their dispersion in water many times a day, leading to loss of...

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Bibliographic Details
Main Authors: Marzia Cirri, Paola A. Mura, Francesca Maestrelli, Simona Benedetti, Susanna Buratti
Format: Article
Language:English
Published: MDPI AG 2024-10-01
Series:Pharmaceutics
Subjects:
pediatric formulation
propranolol HCl
cyclodextrin complexation
orally disintegrating tablets
taste masking
electronic tongue
Online Access:https://www.mdpi.com/1999-4923/16/11/1351
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