Identification of mechanistic CKD biomarkers in a rat SNx kidney fibrosis model by transcriptomics and proteomics detectable in biofluids

Identification of mechanistic CKD biomarkers in a rat SNx kidney fibrosis model by transcriptomics and proteomics detectable in biofluids

Abstract The rat sub-total nephrectomy (SNx) is a functional model of general chronic kidney disease (CKD) where the main pathological driver is glomerular hypertension representative of several subtypes of CKD. Comprehensive transcriptomics and proteomics analyses on the SNx rats were performed to...

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Main Authors: Karin Barnouin, Elisa Tonoli, Clare Coveney, John Atkinson, Margarida Sancho, Andrew Skelton, David J. Boocock, Linghong Huang, Joseph Shephard, Timothy S. Johnson, Elisabetta A. M. Verderio, Breda Twomey
Format: Article
Language:English
Published: Nature Portfolio 2025-04-01
Series:Scientific Reports
Online Access:https://doi.org/10.1038/s41598-025-93894-6
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https://doi.org/10.1038/s41598-025-93894-6

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