Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial

Vagus nerve stimulation in treatment-resistant depression: A one-year, randomized, sham-controlled trial

Background: Few treatments are available for individuals with marked treatment-resistant depression (TRD). Objective: Evaluate the safety and effectiveness of FDA-approved adjunctive vagus nerve stimulation (VNS) in patients with marked TRD. Methods: This 12-month, multicenter, double-blind, sham-co...

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Main Authors: Charles R. Conway, Scott T. Aaronson, Harold A. Sackeim, Mark S. George, John Zajecka, Mark T. Bunker, Walter Duffy, Mary Stedman, Patricio Riva-Posse, Rebecca M. Allen, João Quevedo, Matthew Berger, Gustavo Alva, Mohd A. Malik, David L. Dunner, Ivan Cichowicz, Michael Banov, Lucian Manu, Ziad Nahas, Matthew Macaluso, Brian J. Mickey, Yvette Sheline, Christopher L. Kriedt, Ying-Chieh (Lisa) Lee, Charles Gordon, Olivia Shy, Quyen Tran, Laura Yates, A. John Rush
Format: Article
Language:English
Published: Elsevier 2025-05-01
Series:Brain Stimulation
Subjects:
Treatment-resistant depression
Vagus nerve stimulation
Adjunctive therapy
Efficacy
Response
Partial response
Online Access:http://www.sciencedirect.com/science/article/pii/S1935861X24013901
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