Metabolic reprogramming induced by fructose promotes therapy´s failure in liver cancer cells in vitro and in vivo.

Metabolic reprogramming induced by fructose promotes therapy´s failure in liver cancer cells in vitro and in vivo.

Introduction and Objectives: Metabolic reprogramming is a hallmark of cancer cells. Fructose metabolism is decreased in liver cancer cells to counteract the oxidative environment induced by fructose. Ketohexokinase (KHK) A is overexpressed, and its switch confers advantages to cancer cells. The obje...

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Main Authors: Lisette Chávez-Rodríguez, Oscar A. Escobedo Calvario, Johann Matschke, Verena Jendrossek, Felipe Masso, Araceli Páez Arenas, María C. Gutiérrez-Ruíz, Luis E. Gomez-Quiroz
Format: Article
Language:English
Published: Elsevier 2025-04-01
Series:Annals of Hepatology
Online Access:http://www.sciencedirect.com/science/article/pii/S1665268125000808
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