Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir

Structural and mechanistic bases for resistance of the M66I capsid variant to lenacapavir

ABSTRACT Lenacapavir (LEN) is the first-in-class viral capsid protein (CA) targeting antiretroviral for treating multi-drug-resistant HIV-1 infection. Clinical trials and cell culture experiments have identified resistance-associated mutations (RAMs) in the vicinity of the hydrophobic CA pocket targ...

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Main Authors: Lorenzo Briganti, Arun S. Annamalai, Stephanie M. Bester, Guochao Wei, Jonathan R. Andino-Moncada, Satya P. Singh, Alex B. Kleinpeter, Meghna Tripathi, Binh Nguyen, Rajalingam Radhakrishnan, Parmit K. Singh, Juliet Greenwood, Lauren I. Schope, Reed Haney, Szu-Wei Huang, Eric O. Freed, Alan N. Engelman, Ashwanth C. Francis, Mamuka Kvaratskhelia
Format: Article
Language:English
Published: American Society for Microbiology 2025-05-01
Series:mBio
Subjects:
HIV-1
antiretroviral agents
capsid
drug resistance
structure
Online Access:https://journals.asm.org/doi/10.1128/mbio.03613-24
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https://journals.asm.org/doi/10.1128/mbio.03613-24

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