Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction

Expression of amyotrophic lateral sclerosis associated protein disulfide isomerase A3 D217N variant recapitulates early morphological alterations at the neuromuscular junction

Amyotrophic lateral sclerosis (ALS) is a fatal neurodegenerative disease characterized by neuromuscular connectivity decline followed by motoneuron loss. Altered proteostasis is suggested as a transversal pathogenic mechanism, notably involving dysfunction at the level of the endoplasmic reticulum (...

Full description

Saved in:
Bibliographic Details
Main Authors: Martin Sepulveda, Francisca MartinezTraub, Patricia Ojeda, Jessica Mella, Jorge Ojeda, Cristina Pinto, Rodrigo Diaz, Pablo Rozas, Claudia Sepulveda, Bredford Kerr, Vania Morales, Mirva Saaranen, Lloyd Ruddock, Danilo B. Medinas, Juan Pablo Henriquez, Claudio Hetz
Format: Article
Language:English
Published: Elsevier 2025-10-01
Series:Neurobiology of Disease
Subjects:
Amyotrophic lateral sclerosis
Endoplasmic reticulum
Protein disulfide isomerase
Proteostasis
Neuromuscular junction
Online Access:http://www.sciencedirect.com/science/article/pii/S096999612500261X
Tags: Add Tag
No Tags, Be the first to tag this record!

Internet

http://www.sciencedirect.com/science/article/pii/S096999612500261X

Similar Items