Neurodevelopmental status of children aged 12 to 60 months conceived with artificial oocyte activation in a Cross-Sectional study

Neurodevelopmental status of children aged 12 to 60 months conceived with artificial oocyte activation in a Cross-Sectional study

Abstract The potential effect of artificial oocyte activation (AOA) following intracytoplasmic sperm injection (ICSI) on neurodevelopment remains uncertain. Since AOA does not fully replicate the physiological Ca²⁺ oscillations essential for fertilization, concerns persist regarding its safety. This...

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Bibliographic Details
Main Authors: Kotaro Miyazaki, Mitsutoshi Yamada, Kazuhiro Akashi, Seung Chik Jwa, Hiroki Utsuno, Shintaro Kamijo, Takeshi Arimitsu, Mariko Hida, Yasunori Sato, Yasushi Hirota, Satoshi Narumi, Mamoru Tanaka, Yutaka Osuga, Naoaki Kuji
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Intracytoplasmic sperm injection (ICSI)
Artificial oocyte activation (AOA)
Safety
Ages and stages questionnaires 3rd edition (ASQ-3)
Neurodevelopment
Online Access:https://doi.org/10.1038/s41598-025-12445-1
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