The molecular basis for DNA-binding by competence T4P is distinct in a representative Gram-positive and Gram-negative species.

Competence type IV pili (T4P) are bacterial surface appendages that facilitate DNA uptake during horizontal gene transfer by natural transformation. These dynamic structures actively extend from the cell surface, bind to DNA in the environment, and then retract to import bound DNA into the cell. Com...

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Bibliographic Details
Main Authors: Nicholas D Christman, Ankur B Dalia
Format: Article
Language:English
Published: Public Library of Science (PLoS) 2025-04-01
Series:PLoS Pathogens
Online Access:https://doi.org/10.1371/journal.ppat.1013128
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