SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing

SETDB1 knockdown boosts recombinant protein in CHO cells via epigenetic transcriptional silencing

Abstract Chinese hamster ovary (CHO) cells serve as the predominant mammalian expression system for recombinant protein production. However, clonal heterogeneity and instability in recombinant protein expression remain significant challenges. SET domain bifurcated histone lysine methyltransferase 1...

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Main Authors: Jiang-Tao Lu, Miao Zhang, Yan-Ping Gao, Lu-Lu Yang, Zhao-Ming Cui, Ming-Ming Han, Xi Zhang, Hong-Yan Xu, Xiao-Yin Wang, Le-Le Qiu, Zi-Chun Hua, Tian-Yun Wang, Yan-Long Jia
Format: Article
Language:English
Published: SpringerOpen 2025-07-01
Series:AMB Express
Subjects:
Histone modification
SETDB1
Epigenetic regulation
CHO cells
Transgene expression
Online Access:https://doi.org/10.1186/s13568-025-01914-5
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https://doi.org/10.1186/s13568-025-01914-5

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