Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway

Ursolic and oleanolic acids suppress MNNG induced malignant transformation of human gastric mucosal epithelium by regulating the PI3 K/AKT pathway

Abstract Berberine hydrochloride (Ber) is the primary active compound in the traditional Chinese medicine ‘Huanglian’. Ursolic acid (UA) and oleanolic acid (OA) are the main triterpenoids extracted from ‘Tengligen’. Notably, both Ber and UA/OA exhibit antitumour activity. This study aimed to investi...

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Bibliographic Details
Main Authors: Mingkun Liu, Jinsheng Dong, Li Wang, Yilin Li, Qingjuan Wu, Qi Zheng, Xiaji Zhou, Naili Yao, Runshun Zhang, Wenliang Lyu, Yuning Bai
Format: Article
Language:English
Published: Nature Portfolio 2025-07-01
Series:Scientific Reports
Subjects:
Ursolic acid
Oleanolic acid
PI3 K/AKT pathway
Precancerous lesions of gastric cancer
Berberine hydrochloride
Online Access:https://doi.org/10.1038/s41598-025-03606-3
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https://doi.org/10.1038/s41598-025-03606-3

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