Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning

Identification of aging-related biomarkers for intervertebral disc degeneration in whole blood samples based on bioinformatics and machine learning

IntroductionAging is characterized by gradual structural and functional changes in the body over time, with intervertebral disc degeneration (IVDD) representing a key manifestation of spinal aging and a major contributor to low back pain (LBP).MethodsThis study utilized bioinformatics and machine le...

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Main Authors: Zi-hang Li, Shi-pian Li, Ya-hao Li, Yu-cheng Wang, Zhen-yu Tang, Kai-yang Xu, Xiao-rong Li, Zhen Tan, Jiao-yi Pan, Jin-tao Liu, Hong Jiang, Zhi-jia Ma, Yu-xiang Dai, Peng-fei Yu
Format: Article
Language:English
Published: Frontiers Media S.A. 2025-04-01
Series:Frontiers in Immunology
Subjects:
intervertebral disc degeneration
aging-related biomarkers
bioinformatics
machine learning
immune infiltration analysis
whole blood samples
Online Access:https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565945/full
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https://www.frontiersin.org/articles/10.3389/fimmu.2025.1565945/full

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