Development of a Rapid Method for Residence Time Distribution Measurement in Twin-Screw Wet Granulation Based on Image Processing with Lab Color Space

Development of a Rapid Method for Residence Time Distribution Measurement in Twin-Screw Wet Granulation Based on Image Processing with Lab Color Space

<b>Background/Objectives</b>: In the twin-screw wet granulation (TSWG) process, accurate measurement of residence time distribution (RTD) is critical, as it characterizes material transport kinetics and mixing behavior. It plays a critical role in evaluating the homogeneity and stability...

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Bibliographic Details
Main Authors: Jie Zhao, Geng Tian, Ying Tian, Haibin Qu
Format: Article
Language:English
Published: MDPI AG 2025-07-01
Series:Pharmaceutics
Subjects:
continuous manufacturing (CM)
twin-screw wet granulation (TSWG)
image processing
mean residence time (MRT)
tracer method
Online Access:https://www.mdpi.com/1999-4923/17/7/929
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